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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1211901Generated: October 31, 2026

1,2-Dichloroethane → 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-trimethylsilanylethynylpyrimidine-4-carboxylic acid methyl ester

https://huagongshe.com/reaction/1211901

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantTrimethyl((tributylstannyl)ethynyl)silaneHCID 639663—
Reactant6-Amino-5-bromo-2-(4-chloro-2-fluoro-3-methoxyphenyl)-pyrimidine-4-carboxylic acid methyl esterHCID 59432116—
Product6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-trimethylsilanylethynylpyrimidine-4-carboxylic acid methyl esterHCID 59189594—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
ORD IDord-610fb67ba6604cf3a652407c8501143a
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (5/10)