Benzyl 2-hydroxyacetate → 2-(Benzyloxy)-2-oxoethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 1211909Notes

Reaction equation

HRID 1211909 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH:9]2[C:10]([C:35](=[O:36])[n:37]3[cH:38][cH:39][n:40][cH:41]3)=[C:11]([CH3:34])[N:12]([c:24]3[cH:25][c:26]([C:30]([F:31])([F:32])[F:33])[cH:27][cH:28][cH:29]3)[C:13](=[O:23])[N:14]2[CH2:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[cH:7][cH:8]1.[OH:42][CH2:43][C:44](=[O:45])[O:46][CH2:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH:9]2[C:10]([C:35](=[O:36])[O:42][CH2:43][C:44](=[O:45])[O:46][CH2:47][c:48]3[cH:49][cH:50][cH:51][cH:52][cH:53]3)=[C:11]([CH3:34])[N:12]([c:24]3[cH:25][c:26]([C:30]([F:31])([F:32])[F:33])[cH:27][cH:28][cH:29]3)[C:13](=[O:23])[N:14]2[CH2:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 561337Benzyl 2-hydroxyacetateHCID 59684795tert.-Butyl [6-(4-cyanophenyl)-5-(1H-imidazol-1-ylcarbonyl)-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidin-1(2H)-yl]acetate

Product 1

HCID 596848532-(Benzyloxy)-2-oxoethyl 3-(2-tert.-butoxy-2-oxoethyl)-4-(4-cyanophenyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-69aec8f8182c4104bcc9ce276de96141
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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