HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(5-bromopyridin-2-yl)-2-nitrobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-bromopyridin-2-yl)-2-nitrobenzamide | HCID 679218 | 77.9% |
Reaction Steps
A solution of 2-nitrobenzoyl chloride (3.70 g, 20 mmol, 1.0 equiv), 2-amino-5-bromopyridine (3.50 g, 1.0 equiv), pyridine (10 mL) in 25 mL of methylene chloride was stirred overnight. The volatile was evaporated, flash chromatography on silica gel gave N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide (5.02 g, 77%). MS found for C12H9BrN3O3 (M+H)+: 322.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727982B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f033fc08e413473e9aec011917a7adb6 |
| Source note | uspto-grants-2010_06 |