7-amino-4-(4-hydroxycyclohexyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one → Bis(2,2,2-trifluoroethyl) (4-{[4-{[7-(trans-4-hydroxycyclohexyl)-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate
Reaction equation
[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])([O:25][CH2:26][C:27]([F:28])([F:29])[F:30])=[O:31])[cH:32][cH:33]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:34][c:35]1[cH:36][cH:37][c:38]([CH:46]2[CH2:47][CH2:48][CH:49]([OH:52])[CH2:50][CH2:51]2)[c:39]2[c:43]1[C:42](=[O:44])[N:41]([CH3:45])[CH2:40]2>>[c:2]1([NH:34][c:35]2[cH:36][cH:37][c:38]([CH:46]3[CH2:47][CH2:48][CH:49]([OH:52])[CH2:50][CH2:51]3)[c:39]3[c:43]2[C:42](=[O:44])[N:41]([CH3:45])[CH2:40]3)[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])([O:25][CH2:26][C:27]([F:28])([F:29])[F:30])=[O:31])[cH:32][cH:33]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-669c7a4168e04a9c8f97fb1c44d18d1a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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