Methanol → N4-(3-aminophenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofurane-5-yl)-2,4-pyrimidinediamine

HRID 1212378Notes

Reaction equation

HRID 1212378 reaction equation
[CH3:17][O:18][C:19](=[O:20])[c:21]1[o:22][c:23]2[c:24]([cH:25]1)[cH:26][c:27]([NH2:30])[cH:28][cH:29]2.[CH3:31][OH:32].[NH2:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][c:11]([Cl:16])[n:12][cH:13][c:14]2[F:15])[cH:5][cH:6][cH:7]1>>[NH2:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][c:11]([NH:30][c:27]3[cH:26][c:24]4[c:23]([o:22][c:21]([C:19]([O:18][CH3:17])=[O:20])[cH:25]4)[cH:29][cH:28]3)[n:12][cH:13][c:14]2[F:15])[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 10845388Methyl 5-aminobenzofuran-2-carboxylateHCID 22061009N4-(3-aminophenyl)-2-chloro-5-fluoro-4-pyrimidineamine

Product 1

HCID 22060867N4-(3-aminophenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofurane-5-yl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-db2bc968a35d452fae2c5a7722b24a25
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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