6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → 6-(cyclopropylmethoxy)-N-[2-cyclopropyl-1-(1,3-thiazol-2-yl)ethyl]-5-(3,3-difluoroazetidin-1-yl)pyridine-2-carboxamide
Reaction equation
[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:13])[OH:14])[n:11]2)[CH2:2][CH2:3]1.[CH:21]1([CH2:24][CH:25]([c:26]2[s:27][cH:28][cH:29][n:30]2)[NH:31][C:32]([c:33]2[cH:34][cH:35][c:36]([CH:37]3[CH2:38][CH2:39][O:40][CH2:41][CH2:42]3)[c:43]([O:44][CH2:45][CH:46]3[CH2:47][CH2:48]3)[n:49]2)=[O:50])[CH2:22][CH2:23]1>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:14])[NH:31][CH:25]([CH2:24][CH:21]3[CH2:22][CH2:23]3)[c:26]3[s:27][cH:28][cH:29][n:30]3)[n:11]2)[CH2:2][CH2:3]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-d70d1e082df348279104b56f60a9b403
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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