2-Bromo-6-(methylsulfonyl)pyridine → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(methylsulfonyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 121279Notes

Reaction equation

HRID 121279 reaction equation
[Br:21][c:22]1[n:23][c:24]([S:28](=[O:29])(=[O:30])[CH3:31])[cH:25][cH:26][cH:27]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:22]1[n:23][c:24]([S:28](=[O:29])(=[O:30])[CH3:31])[cH:25][cH:26][cH:27]1

Participants

3

Reactant 2

HCID 134334222-Bromo-6-(methylsulfonyl)pyridineHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595260125-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(methylsulfonyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-8f850af526264a0bab8663875d58588a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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