Dichloromethane → 4-[4-(3-Chloro-4-fluoro-phenyl)-1-(2-methanesulfonyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1213430Notes

Reaction equation

HRID 1213430 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15]([CH2:27][CH2:28][OH:29])[cH:16][c:17](-[c:19]3[cH:20][c:21]([Cl:26])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1.[CH3:30][S:31]([Cl:32])(=[O:33])=[O:34].[Cl:35][CH2:36][Cl:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15]([CH2:27][CH2:28][O:29][S:31]([CH3:30])(=[O:33])=[O:34])[cH:16][c:17](-[c:19]3[cH:20][c:21]([Cl:26])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 672649094-[4-(3-Chloro-4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 866415984-[4-(3-Chloro-4-fluoro-phenyl)-1-(2-methanesulfonyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-efb83e4f55054234bd2e01d8fc2409f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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