1,2-Dimethoxyethane → Tert-butyl 2,2,2-trifluoro-1-(4-(4-phenylpyrimidin-2-ylamino)phenyl)ethylcarbamate
Reaction equation
[Br:14][c:15]1[cH:16][cH:17][c:18]([CH:21]([C:22]([F:23])([F:24])[F:25])[NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[cH:19][cH:20]1.[C:34](=[O:35])([O-:36])[O-:37].[CH3:96][O:97][CH2:98][CH2:99][O:100][CH3:101].[Cs+:38].[Cs+:39].[O:42]=[C:43]([CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)[CH:52]=[CH:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1.[O:60]=[C:61]([CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1)[CH:70]=[CH:71][c:72]1[cH:73][cH:74][cH:75][cH:76][cH:77]1.[O:78]=[C:79]([CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1)[CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1.[Pd:40].[Pd:41].[c:1]1(-[c:7]2[n:8][c:9]([NH2:13])[n:10][cH:11][cH:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[n:8][c:9]([NH:13][c:15]3[cH:16][cH:17][c:18]([CH:21]([C:22]([F:23])([F:24])[F:25])[NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[cH:19][cH:20]3)[n:10][cH:11][cH:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-9f06b227f7db487db8b6970bc2d781fb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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