Acetic Acid → 5-Amino-8-cyclopropyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 1214059Notes

Reaction equation

HRID 1214059 reaction equation
[CH3:23][OH:24].[CH3:25][C:26](=[O:27])[OH:28].[Cl:20][CH2:21][Cl:22].[N:1](=[N+:2]=[N-:3])[c:4]1[cH:5][c:6](=[O:19])[n:7]([CH:16]2[CH2:17][CH2:18]2)[c:8]2[n:9][c:10]([S:14][CH3:15])[n:11][cH:12][c:13]12.[OH-:29].[OH-:31].[Pd+2:30]>>[NH2:1][c:4]1[cH:5][c:6](=[O:19])[n:7]([CH:16]2[CH2:17][CH2:18]2)[c:8]2[n:9][c:10]([S:14][CH3:15])[n:11][cH:12][c:13]12

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 887MethanolHCID 961Hydroxide2×HCID 6344DichloromethaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57929482HCID 57929482, compound

Product 1

HCID 579294555-Amino-8-cyclopropyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Sources & evidence

ORD record
ord-695fa65f4e894ced8c083bd5fb14d9d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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