Ethyl 3-hydroxy-3-(2-phenylethynyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate → Tert-butyl 4-hydroxy-4-(2-phenylethynyl)-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate

HRID 1214530Notes

Reaction equation

HRID 1214530 reaction equation
[O:25]=[C:26]1[CH2:27][CH2:28][O:29][C:30]2([CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2.[OH:1][C:2]1([C:17]#[C:18][c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[CH2:3][C:4]2([CH2:5][CH2:6][N:7]([C:8]([O:9][CH2:10][CH3:11])=[O:12])[CH2:13][CH2:14]2)[O:15][CH2:16]1>>[C:17](#[C:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[C:26]1([OH:25])[CH2:27][CH2:28][O:29][C:30]2([CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2

Participants

3

Reactant 2

HCID 57493817Ethyl 3-hydroxy-3-(2-phenylethynyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylateHCID 57493827Tert-butyl 4-oxo-1-oxa-9-azaspiro(5.5)undecane-9-carboxylate

Product 1

HCID 57493828Tert-butyl 4-hydroxy-4-(2-phenylethynyl)-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate

Sources & evidence

ORD record
ord-0a83b811bda44f21940064b17a7c5e95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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