Acetic Acid → 3-Amino-3-(2-fluoro-biphenyl-4-yl)-propionic acid ethyl ester

HRID 1214558Notes

Reaction equation

HRID 1214558 reaction equation
[C:40]([OH:41])(=[O:42])[CH3:43].[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][CH:6]([c:7]1[cH:8][c:9]([F:19])[c:10](-[c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[cH:11][cH:12]1)[N:20]([CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[CH3:35])=[O:36].[CH3:37][CH2:38][OH:39].[OH-:44].[OH-:45].[Pd+2:46]>>[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][CH:6]([c:7]1[cH:8][c:9]([F:19])[c:10](-[c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[cH:11][cH:12]1)[NH2:20])=[O:36]

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 69779747Ethyl 3-[benzyl(1-phenylethyl)amino]-3-(3-fluoro-4-phenylphenyl)propanoate

Product 1

HCID 544941723-Amino-3-(2-fluoro-biphenyl-4-yl)-propionic acid ethyl ester

Sources & evidence

ORD record
ord-79cd0147e91148a4b8d479854689dff3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…