Ethylene Glycol → 4-i-Propyl-phenyl sulfamic acid-[6-(2-hydroxy-ethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidin-4-yl]-amide

HRID 1214589Notes

Reaction equation

HRID 1214589 reaction equation
[CH2:43]([CH2:44][O:45][CH3:46])[O:47][CH3:48].[Cl:7][c:8]1[c:9]([O:34][c:35]2[c:36]([O:41][CH3:42])[cH:37][cH:38][cH:39][cH:40]2)[c:10]([NH:20][S:21]([NH:22][c:23]2[cH:24][cH:25][c:26]([CH:29]([CH3:30])[CH3:31])[cH:27][cH:28]2)(=[O:32])=[O:33])[n:11][c:12](-[c:14]2[cH:15][cH:16][n:17][cH:18][cH:19]2)[n:13]1.[H-:1].[Na+:2].[OH:3][CH2:4][CH2:5][OH:6]>>[OH:3][CH2:4][CH2:5][O:6][c:8]1[c:9]([O:34][c:35]2[c:36]([O:41][CH3:42])[cH:37][cH:38][cH:39][cH:40]2)[c:10]([NH:20][S:21]([NH:22][c:23]2[cH:24][cH:25][c:26]([CH:29]([CH3:30])[CH3:31])[cH:27][cH:28]2)(=[O:32])=[O:33])[n:11][c:12](-[c:14]2[cH:15][cH:16][n:17][cH:18][cH:19]2)[n:13]1

Participants

6

Reactant 5

HCID 174Ethylene GlycolHCID 923Sodium ionHCID 80711,2-DimethoxyethaneHCID 166653HydrideHCID 102798684-i-Propyl-phenyl sulfamic acid-[6-chloro-5-(o-methoxy-phenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide

Product 1

HCID 103028114-i-Propyl-phenyl sulfamic acid-[6-(2-hydroxy-ethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidin-4-yl]-amide

Sources & evidence

ORD record
ord-0d704e016a7e4bdf820a4009b6194f0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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