1-(Bromomethyl)-3-(trifluoromethyl)benzene → 1-(5-Acetyl-4-methylthiazol-2-yl)-3-(3-(trifluoromethyl)benzyl)imidazolidin-2-one

HRID 1214760Notes

Reaction equation

HRID 1214760 reaction equation
[C:18]([CH3:19])(=[O:20])[c:21]1[c:22]([CH3:32])[n:23][c:24]([N:26]2[C:27](=[O:31])[NH:28][CH2:29][CH2:30]2)[s:25]1.[CH3:1][c:2]1[n:3][c:4](-[n:5]2[c:6](=[O:7])[nH:8][n:9][cH:10]2)[s:11][c:12]1[C:13]([O:14][CH2:15][CH3:16])=[O:17].[F:33][C:34]([c:35]1[cH:36][c:37]([CH2:38][Br:39])[cH:40][cH:41][cH:42]1)([F:43])[F:44]>>[C:18]([CH3:19])(=[O:20])[c:21]1[c:22]([CH3:32])[n:23][c:24]([N:26]2[C:27](=[O:31])[N:28]([CH2:38][c:37]3[cH:36][c:35]([C:34]([F:33])([F:43])[F:44])[cH:42][cH:41][cH:40]3)[CH2:29][CH2:30]2)[s:25]1

Participants

4

Reactant 3

HCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzeneHCID 579197381-(5-Acetyl-4-methylthiazol-2-yl)imidazolidin-2-oneHCID 57920013ethyl 4-methyl-2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)thiazole-5-carboxylate

Product 1

HCID 579198511-(5-Acetyl-4-methylthiazol-2-yl)-3-(3-(trifluoromethyl)benzyl)imidazolidin-2-one

Sources & evidence

ORD record
ord-1d1d86b1a1154b8984a1665251cf041e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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