Methanol → 7-Chloro-1-(2,3-dihydroxypropyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Reaction equation
[CH3:32][OH:33].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:24]1)[C:7]([c:17]1[c:18]([F:23])[cH:19][cH:20][cH:21][cH:22]1)=[N:8][CH2:9][C:10](=[O:16])[N:11]2[CH2:12][CH:13]1[CH2:14][O:15]1.[Na+:31].[OH-:30].[S:25]([OH:26])(=[O:27])(=[O:28])[OH:29]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:24]1)[C:7]([c:17]1[c:18]([F:23])[cH:19][cH:20][cH:21][cH:22]1)=[N:8][CH2:9][C:10](=[O:16])[N:11]2[CH2:12][CH:13]([CH2:14][OH:15])[OH:26]Participants
6
Sources & evidence
- ORD record
- ord-16baab06828b419e8ec9bb4570b81d7a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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