Dichloromethane → 5-Amino-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2,6-dihydrospiro[[1,4]oxazine-3,9'-xanthen]-2'-ol

HRID 1216221Notes

Reaction equation

HRID 1216221 reaction equation
[B:31]([Br:32])([Br:33])[Br:34].[Cl:35][CH2:36][Cl:37].[F:1][c:2]1[cH:3][c:4]([O:29][CH3:30])[cH:5][c:6]2[c:7]1[O:8][c:9]1[cH:10][cH:11][c:12](-[c:22]3[c:23]([F:28])[n:24][cH:25][cH:26][cH:27]3)[cH:13][c:14]1[C:15]21[CH2:16][O:17][CH2:18][C:19]([NH2:21])=[N:20]1>>[F:1][c:2]1[cH:3][c:4]([OH:29])[cH:5][c:6]2[c:7]1[O:8][c:9]1[cH:10][cH:11][c:12](-[c:22]3[c:23]([F:28])[n:24][cH:25][cH:26][cH:27]3)[cH:13][c:14]1[C:15]21[CH2:16][O:17][CH2:18][C:19]([NH2:21])=[N:20]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 674375114'-Fluoro-7'-(2-fluoropyridin-3-yl)-2'-methoxy-2,6-dihydrospiro[[1,4]oxazine-3,9'-xanthen]-5-amine

Product 1

HCID 674401225-Amino-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2,6-dihydrospiro[[1,4]oxazine-3,9'-xanthen]-2'-ol

Sources & evidence

ORD record
ord-5846b50ec6c840668b3598694de130fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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