Toluene → 2-Bromo-5-(2-pyrazolyl)thiophene

HRID 1216507Notes

Reaction equation

HRID 1216507 reaction equation
[Br:1][c:2]1[s:3][c:4]([Br:7])[cH:5][cH:6]1.[CH2:8]([Sn:9]([CH2:10][CH2:11][CH2:12][CH3:18])([n:13]1[n:14][cH:15][cH:16][cH:17]1)[CH2:19][CH2:20][CH2:21][CH3:22])[CH2:23][CH2:24][CH3:25].[CH3:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[cH:33]1[cH:34][cH:35][c:36]([P:37]([Pd:38]([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)[cH:108][cH:109]1>>[Br:1][c:2]1[s:3][c:4](-[n:13]2[n:14][cH:15][cH:16][cH:17]2)[cH:5][cH:6]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 184532,5-DibromothiopheneHCID 3059331-(Tributylstannyl)-1H-pyrazoleHCID 178420554HCID 178420554, compound

Product 1

HCID 125544912-Bromo-5-(2-pyrazolyl)thiophene

Sources & evidence

ORD record
ord-508b6096b5584bbd9598fd6b79a929a3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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