HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12166Generated: October 27, 2026
Triethylamine → N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]phenyl} (4-{[(1-methyl(2-imidazolin-2-yl))amino]methyl}phenyl)carboxamide
https://huagongshe.com/reaction/12166
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-methyl-2-methylsulfanyl-4,5-dihydro-1H-imidazole | HCID 10396874 | — |
| Reactant | [4-(Aminomethyl)phenyl]-n-{2-[n-(5-chloro(2-pyridyl))carbamoyl]phenyl}carboxamide | HCID 18727608 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]phenyl} (4-{[(1-methyl(2-imidazolin-2-yl))amino]methyl}phenyl)carboxamide | HCID 22596379 | 65% |
Reaction Steps
A mixture of [4-(aminomethyl)phenyl]-N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]phenyl}carboxamide (74 mg, 0.195 mmol), 1-methyl-2-methylthio-2-imidazoline (25 mg, 0.195 mmol), NEt3 (2 mL) and pyridine (5 mL) was stirred at 80° C. overnight, concentrated and HPLC (C18 reversed phase) eluting with 0.1% TFA in H2O/CH3CN gave N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]phenyl}(4-{[(1-methyl(2-imidazolin-2-yl))amino]methyl}phenyl)carboxamide (52 mg, 65%). MS found for C24H23ClN6O2 (M+H)+: 463.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07727981B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-30a4b1acec744fe7ac7ca91be30e3f4f |
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| Source note | uspto-grants-2010_06 |
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