HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12168Generated: October 31, 2026
Triethylamine → (2-{[4-(Amino(hydroxyimino)methyl)phenyl]carbonylamino}-5-methoxyphenyl)-n-(5-chloro(2-pyridyl))carboxamide
https://huagongshe.com/reaction/12168
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | N-(5-chloropyridin-2-yl)-2-(4-cyanobenzamido)-5-methoxybenzamide | HCID 22596384 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2-{[4-(Amino(hydroxyimino)methyl)phenyl]carbonylamino}-5-methoxyphenyl)-n-(5-chloro(2-pyridyl))carboxamide | HCID 73460741 | — |
Reaction Steps
To a suspension of compound N-(5-chloro(2-pyridyl)) {2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}carboxamide (150 mg) in EtOH (10 mL) was added hydroxyamine hydrochloride (80 mg) and Et3N (200 μL). The mixture was stirred at 60° C. overnight and the reaction was complete. The solvent was evaporated and the crude material was purified by RP-HPLC to give the title compound. MS found for C21H18ClN5O4 (M+H)+: 440.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07727981B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-82bf9b1954454b0fb3915cb4422c3e72 |
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| Source note | uspto-grants-2010_06 |
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