3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole → 5-Chloro-thiophene-2-carboxylic acid {2-[[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide

HRID 121682Notes

Reaction equation

HRID 121682 reaction equation
[Br:1][CH2:2][c:3]1[n:4][o:5][c:6](-[c:8]2[s:9][c:10]([Cl:13])[cH:11][cH:12]2)[cH:7]1.[CH:14]([CH3:15])([CH3:16])[N:17]1[CH2:18][CH2:19][CH:20]([NH:23][S:24](=[O:25])(=[O:26])[CH2:27][CH2:28][NH:29][C:30](=[O:31])[c:32]2[s:33][c:34]([Cl:37])[cH:35][cH:36]2)[CH2:21][CH2:22]1>>[CH2:2]([c:3]1[n:4][o:5][c:6](-[c:8]2[s:9][c:10]([Cl:13])[cH:11][cH:12]2)[cH:7]1)[N:23]([CH:20]1[CH2:19][CH2:18][N:17]([CH:14]([CH3:15])[CH3:16])[CH2:22][CH2:21]1)[S:24](=[O:25])(=[O:26])[CH2:27][CH2:28][NH:29][C:30](=[O:31])[c:32]1[s:33][c:34]([Cl:37])[cH:35][cH:36]1

Participants

3

Reactant 2

HCID 111501463-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazoleHCID 119904785-Chloro-Thiophene-2-Carboxylic Acid [2-(1--Isopropyl-Piperidin-4-Ylsulfamoyl)-Ethyl]-Amide

Product 1

HCID 666249695-Chloro-thiophene-2-carboxylic acid {2-[[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide

Sources & evidence

ORD record
ord-10bc7de087f6456289a698937088c736
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…