5-Bromo-2,4-dimethoxybenzaldehyde → 2-(5-Formyl-2,4-dimethoxyphenyl)indole-1-carboxylic acid tert-butyl ester

HRID 1216837Notes

Reaction equation

HRID 1216837 reaction equation
[Br:1][c:2]1[c:3]([O:12][CH3:13])[cH:4][c:5]([O:10][CH3:11])[c:6]([CH:7]=[O:8])[cH:9]1.[C:14](=[O:15])([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[n:21]1[c:22]([B:30]([OH:31])[OH:32])[cH:23][c:24]2[cH:25][cH:26][cH:27][cH:28][c:29]12.[s:33]1[c:34](-[c:35]2[c:36]([O:37][CH3:38])[cH:39][c:40]([O:41][CH3:42])[c:43]([CH:45]=[O:46])[cH:44]2)[cH:47][c:48]2[cH:49][cH:50][cH:51][cH:52][c:53]12>>[c:2]1(-[c:22]2[n:21]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[c:29]3[c:24]([cH:23]2)[cH:25][cH:26][cH:27][cH:28]3)[c:3]([O:12][CH3:13])[cH:4][c:5]([O:10][CH3:11])[c:6]([CH:7]=[O:8])[cH:9]1

Participants

4

Reactant 3

HCID 6683465-Bromo-2,4-dimethoxybenzaldehydeHCID 27733021-(tert-Butoxycarbonyl)indole-2-boronic Acid (contains varying amounts of Anhydride)HCID 161159165-Benzo[b]thiophen-2-yl-2,4-dimethoxy-benzaldehyde

Product 1

HCID 161163072-(5-Formyl-2,4-dimethoxyphenyl)indole-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-43a2032077eb408aa5d68a3fa159a30d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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