3-Pyridinemethanamine → 5-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methyl-N-(pyridin-3-ylmethyl)thiophene-2-carboxamide

HRID 1217067Notes

Reaction equation

HRID 1217067 reaction equation
[CH3:1][c:2]1[cH:3][c:4]([N:5]2[CH2:6][CH2:7][N:8]([CH2:9][c:10]3[cH:11][cH:12][c:13]([C:14]([F:15])([F:16])[F:17])[cH:18][cH:19]3)[C:20]2=[O:21])[s:22][c:23]1[C:24]([OH:25])=[O:26].[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:47])[N:35]([c:38]3[cH:39][c:40]([CH3:46])[c:41]([C:43](=[O:44])[OH:45])[s:42]3)[CH2:36][CH2:37]2)[cH:48][cH:49]1.[NH2:50][CH2:51][c:52]1[cH:53][n:54][cH:55][cH:56][cH:57]1>>[F:27][c:28]1[cH:29][cH:30][c:31]([CH2:32][N:33]2[C:34](=[O:47])[N:35]([c:38]3[cH:39][c:40]([CH3:46])[c:41]([C:43](=[O:45])[NH:50][CH2:51][c:52]4[cH:53][n:54][cH:55][cH:56][cH:57]4)[s:42]3)[CH2:36][CH2:37]2)[cH:48][cH:49]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 580314655-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylic acidHCID 580315813-Methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylic acid

Product 1

HCID 594812595-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3-methyl-N-(pyridin-3-ylmethyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-83b40b58fb004c13b106c23ba8353a9a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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