Toluene → (RS)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

HRID 1217189Notes

Reaction equation

HRID 1217189 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([cH:19]1)[CH2:14][CH:15]([CH2:17][Br:18])[O:16]2.[CH3:20][c:21]1[cH:22][cH:23][c:24]([CH2:25][C:26]2([OH:32])[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[cH:33][cH:34]1.[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([cH:19]1)[CH2:14][CH:15]([CH2:17][N:29]1[CH2:28][CH2:27][C:26]([CH2:25][c:24]3[cH:23][cH:22][c:21]([CH3:20])[cH:34][cH:33]3)([OH:32])[CH2:31][CH2:30]1)[O:16]2

Participants

4

Reactant 3

HCID 1140TolueneHCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran

Product 1

HCID 22628351(RS)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-ca953b004df64fc5a91566b3b48c3b23
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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