(2RS)-bromo-N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-propionamide → N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-acrylamide

HRID 121741Notes

Reaction equation

HRID 121741 reaction equation
[Br:1][CH:2]([C:3](=[O:4])[NH:5][C:6]([CH2:7][OH:8])([CH3:9])[c:10]1[c:11]([F:17])[cH:12][cH:13][c:14]([Br:16])[cH:15]1)[CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[CH2:25]([CH:26]1[C:27](=[O:28])[NH:29][C:30]([c:31]2[cH:32][c:33]([Br:34])[cH:35][cH:36][c:37]2[F:38])([CH3:39])[CH2:40][O:41]1)[c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[CH2:48]([CH:49]1[C:50](=[O:51])[NH:52][C:53]([c:54]2[cH:55][c:56]([Br:57])[cH:58][cH:59][c:60]2[F:61])([CH3:62])[CH2:63][O:64]1)[c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[CH:2]([C:3](=[O:4])[NH:5][C:6]([CH2:7][OH:8])([CH3:9])[c:10]1[c:11]([F:17])[cH:12][cH:13][c:14]([Br:16])[cH:15]1)=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1

Participants

3

Reactant 2

HCID 58155233(2RS)-bromo-N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-propionamideHCID 178421534HCID 178421534, compound2×

Product 1

HCID 66931645N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-acrylamide

Sources & evidence

ORD record
ord-d982d573f93a43439a3b8a0148bc2a44
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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