Carbonate Ion → N-(4-(7-(3-(1-hydroxycyclopropyl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

HRID 1217503Notes

Reaction equation

HRID 1217503 reaction equation
[C:50](=[O:51])([O-:52])[O-:53].[CH3:38][S:39]([O:40][CH2:43][CH2:44][CH2:45][C:46]1([OH:49])[CH2:47][CH2:48]1)(=[O:41])=[O:42].[Cs+:54].[Cs+:55].[OH:1][c:2]1[c:3]([O:36][CH3:37])[cH:4][c:5]2[c:6]([O:12][c:13]3[c:14]([F:35])[cH:15][c:16]([N:19]([C:20](=[O:21])[C:22]4([C:25](=[O:26])[NH2:27])[CH2:23][CH2:24]4)[c:28]4[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]4)[cH:17][cH:18]3)[cH:7][cH:8][n:9][c:10]2[cH:11]1>>[O:1]([c:2]1[c:3]([O:36][CH3:37])[cH:4][c:5]2[c:6]([O:12][c:13]3[c:14]([F:35])[cH:15][c:16]([N:19]([C:20](=[O:21])[C:22]4([C:25](=[O:26])[NH2:27])[CH2:23][CH2:24]4)[c:28]4[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]4)[cH:17][cH:18]3)[cH:7][cH:8][n:9][c:10]2[cH:11]1)[CH2:43][CH2:44][CH2:45][C:46]1([OH:49])[CH2:47][CH2:48]1

Participants

5

Reactant 4

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 86640796HCID 86640796, compoundHCID 136347983N-(3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Product 1

HCID 67299435N-(4-(7-(3-(1-hydroxycyclopropyl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-ef342f6bdf134c4aaa2937681a0fd456
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…