Pyridine → N-(5-chloro-2-fluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 121788Notes

Reaction equation

HRID 121788 reaction equation
[CH2:1]([CH3:2])[O:3][c:4]1[c:5]([C:18](=[O:19])[Cl:20])[c:6](=[O:17])[n:7](-[c:10]2[cH:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)[cH:8][cH:9]1.[Cl:21][c:22]1[c:23]([O:30][c:31]2[c:32](-[c:37]3[cH:38][n:39][n:40]([CH3:42])[cH:41]3)[cH:33][n:34][cH:35][cH:36]2)[cH:24][c:25]([F:29])[c:26]([NH2:28])[cH:27]1.[Cl:43][CH2:44][Cl:45].[cH:46]1[cH:47][cH:48][n:49][cH:50][cH:51]1>>[CH2:1]([CH3:2])[O:3][c:4]1[c:5]([C:18](=[O:19])[NH:28][c:26]2[c:25]([F:29])[cH:24][c:23]([O:30][c:31]3[c:32](-[c:37]4[cH:38][n:39][n:40]([CH3:42])[cH:41]4)[cH:33][n:34][cH:35][cH:36]3)[c:22]([Cl:21])[cH:27]2)[c:6](=[O:17])[n:7](-[c:10]2[cH:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)[cH:8][cH:9]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 674688535-chloro-2-fluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)benzenamineHCID 866675054-Ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

Product 1

HCID 54596551N-(5-chloro-2-fluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-589749e215bc49fa9d547fffe2f647c0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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