7-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one → 7'-fluoro-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 121816Notes

Reaction equation

HRID 121816 reaction equation
[CH:34]1([CH2:35][CH2:36][N:37]2[c:38]3[c:39]([cH:40][cH:41][cH:42][cH:43]3)[C:44]([c:45]3[c:46]([OH:47])[cH:48][c:49]4[c:53]([cH:54]3)[O:52][CH2:51][O:50]4)([CH2:55][OH:56])[C:57]2=[O:58])[CH2:59][CH2:60]1.[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[N:9]([CH2:11][c:12]1[o:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]1)[C:8](=[O:21])[C:7]2([CH2:22][OH:23])[c:24]1[cH:25][c:26]2[c:27]([cH:31][c:32]1[OH:33])[O:28][CH2:29][O:30]2>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[N:9]([CH2:11][c:12]1[o:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]1)[C:8](=[O:21])[C:7]21[CH2:22][O:23][c:32]2[c:24]1[cH:25][c:26]1[c:27]([cH:31]2)[O:28][CH2:29][O:30]1

Participants

3

Reactant 2

HCID 588724597-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-oneHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592634667'-fluoro-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-866500d8f1ab4adb8b5e63005aa42eb9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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