1-(Difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid → 1-(Difluoromethyl)-5-[5-(4-fluorophenyl)-5-(2-fluoro-4-pyridinyl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridin-2-one

HRID 1218191Notes

Reaction equation

HRID 1218191 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH:9]([CH3:10])[NH2:11])([NH2:12])[c:13]2[cH:14][c:15]([F:19])[n:16][cH:17][cH:18]2)[cH:6][cH:7]1.[F:20][CH:21]([n:22]1[c:23](=[O:31])[cH:24][cH:25][c:26]([C:28]([OH:29])=[O:30])[cH:27]1)[F:32]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([c:13]3[cH:14][c:15]([F:19])[n:16][cH:17][cH:18]3)[CH:9]([CH3:10])[NH:11][C:28]([c:26]3[cH:25][cH:24][c:23](=[O:31])[n:22]([CH:21]([F:20])[F:32])[cH:27]3)=[N:12]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 218858751-(Difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acidHCID 218858771-(4-Fluorophenyl)-1-(2-fluoro-4-pyridinyl)propane-1,2-diamine

Product 1

HCID 1784325811-(Difluoromethyl)-5-[5-(4-fluorophenyl)-5-(2-fluoro-4-pyridinyl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridin-2-one

Sources & evidence

ORD record
ord-868685d2849a41318b9f7a5701dd5d1a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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