Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12186Generated: October 26, 2026

2-Chloronicotinic acid → 2-chloro-N-[6-chloro-7-(4-methyl-piperazin-1-yl)-9H-beta-carbolin-8-yl]-nicotinamide

https://huagongshe.com/reaction/12186

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloronicotinic acidHCID 76258—
Reactant6-chloro-7-(4-methyl-piperazin-1-yl)-8-amino-9H-beta-carbolineHCID 67166737—
Product2-chloro-N-[6-chloro-7-(4-methyl-piperazin-1-yl)-9H-beta-carbolin-8-yl]-nicotinamideHCID 1134002225%

Reaction Steps

The desired compound was prepared according to Method A from 6-chloro-7-(4-methyl-piperazin-1-yl)-8-amino-9H-β-carboline and 2-chloro-nicotinic acid in 25% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07727985B2
Source datasetuspto-grants-2010_06
ORD IDord-e81169359fb94455a9946173265fc171
Source noteuspto-grants-2010_06