4-carboxy-2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one → 2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 1218718Notes

Reaction equation

HRID 1218718 reaction equation
[C:33](=[O:34])([OH:35])[c:36]1[c:37](=[O:59])[n:38]([CH2:51][c:52]2[cH:53][cH:54][c:55]([Cl:58])[cH:56][cH:57]2)[n:39][c:40](-[c:42]2[cH:43][cH:44][c:45]3[c:46]([cH:50]2)[CH2:47][CH2:48][O:49]3)[cH:41]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8](=[O:9])[c:10]([CH2:11][N:12]3[CH2:13][CH2:14][N:15]([CH3:16])[CH2:17][CH2:18]3)[cH:19][c:20](-[c:21]3[cH:22][cH:23][c:24]4[c:28]([cH:29]3)[CH2:27][CH2:26][O:25]4)[n:30]2)[cH:31][cH:32]1>>[CH2:33]([OH:34])[c:36]1[c:37](=[O:59])[n:38]([CH2:51][c:52]2[cH:53][cH:54][c:55]([Cl:58])[cH:56][cH:57]2)[n:39][c:40](-[c:42]2[cH:43][cH:44][c:45]3[c:46]([cH:50]2)[CH2:47][CH2:48][O:49]3)[cH:41]1

Participants

3

Reactant 2

HCID 230941294-carboxy-2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneHCID 230941322-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

Product 1

HCID 230941252-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-492ac98d90e24059b3ce68fce09b192c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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