Pyridine → N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

HRID 1218741Notes

Reaction equation

HRID 1218741 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:26])[c:21]([NH2:22])[cH:23][cH:24][cH:25]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1.[Cl:45][CH2:46][Cl:47].[F:33][c:34]1[c:35]([S:41](=[O:42])(=[O:43])[Cl:44])[cH:36][c:37]([F:40])[cH:38][cH:39]1.[cH:27]1[cH:28][cH:29][n:30][cH:31][cH:32]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:26])[c:21]([NH:22][S:41]([c:35]4[c:34]([F:33])[cH:39][cH:38][c:37]([F:40])[cH:36]4)(=[O:42])=[O:43])[cH:23][cH:24][cH:25]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 57990019HCID 57990019, compound

Product 1

HCID 57990014N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-2d979a356a7f4de284518459d2978bab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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