1-(Methanesulfonyl)piperidin-4-amine → N-{2-Fluoro-3-[2-(1-methylethyl)-5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}-1,3-thiazole-2-sulfonamide

HRID 1218763Notes

Reaction equation

HRID 1218763 reaction equation
[CH3:32][S:33](=[O:34])(=[O:35])[N:36]1[CH2:37][CH2:38][CH:39]([NH2:42])[CH2:40][CH2:41]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[c:17]([F:31])[c:18]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[s:27][cH:28][cH:29][n:30]4)[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1>>[c:2]1([NH:42][CH:39]2[CH2:38][CH2:37][N:36]([S:33]([CH3:32])(=[O:34])=[O:35])[CH2:41][CH2:40]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[c:17]([F:31])[c:18]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[s:27][cH:28][cH:29][n:30]4)[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 113558261-(Methanesulfonyl)piperidin-4-amineHCID 57989754N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1,3-thiazole-2-sulfonamide

Product 1

HCID 57989949N-{2-Fluoro-3-[2-(1-methylethyl)-5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}-1,3-thiazole-2-sulfonamide

Sources & evidence

ORD record
ord-58a651eb72f341d39b8a920c373fbd64
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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