Formic Acid → 4'-Trifluoromethylbiphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

HRID 1218827Notes

Reaction equation

HRID 1218827 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([NH:17][C:18](=[O:19])[c:20]3[c:21](-[c:26]4[cH:27][cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]4)[cH:22][cH:23][cH:24][cH:25]3)[cH:14][c:15]2[CH2:16]1)([CH3:5])([CH3:6])[CH3:36].[CH:37]([OH:38])=[O:39]>>[NH2:7][CH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([NH:17][C:18](=[O:19])[c:20]3[c:21](-[c:26]4[cH:27][cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]4)[cH:22][cH:23][cH:24][cH:25]3)[cH:14][c:15]2[CH2:16]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 70184229{5-[(4'-Trifluoromethylbiphenyl-2-carbonyl)-amino]indan-2-yl}-carbamic acid tert-butyl ester

Product 1

HCID 212533824'-Trifluoromethylbiphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

Sources & evidence

ORD record
ord-8c81a6c959d2447581a362c1f81c18dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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