Acetonitrile → 5-Chloro-N-({3-[3-fluoro-4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide

HRID 1219042Notes

Reaction equation

HRID 1219042 reaction equation
[C:29](=[O:30])=[C:31]1[N:32]=[CH:33][CH:34]=[N:35]1.[CH3:36][N:37]([c:38]1[cH:39][cH:40][cH:41][cH:42][n:43]1)[CH3:44].[CH3:45][C:46]#[N:47].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][CH:11]([CH2:12][NH:13][c:14]2[cH:15][c:16]([F:27])[c:17]([N:20]3[C:21](=[O:26])[CH2:22][O:23][CH2:24][CH2:25]3)[cH:18][cH:19]2)[OH:28])[s:6]1.[O:48]1[CH2:49][CH2:50][O:51][CH2:52][CH2:53]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][CH:11]2[CH2:12][N:13]([c:14]3[cH:15][c:16]([F:27])[c:17]([N:20]4[C:21](=[O:26])[CH2:22][O:23][CH2:24][CH2:25]4)[cH:18][cH:19]3)[C:29](=[O:30])[O:28]2)[s:6]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 218852-DimethylaminopyridineHCID 312751,4-DioxaneHCID 13571086CarbonylimidazoleHCID 210707105-Chloro-N-(3-{[3-fluoro-4-(3-oxo-4-morpholinyl)phenyl]amino}-2-hydroxypropyl)-2-thiophenecarboxamide

Product 1

HCID 210707095-Chloro-N-({3-[3-fluoro-4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-2c70dbc86a2a471fb00ccc7dc640fc2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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