Acetic Acid → 1-[(10-Chloro-4,6-dihydro-4-oxo-3-phenylpyrido[2,1-a]isoindole-1-yl)carbonyl]-3-methoxyazetidine

HRID 1219369Notes

Reaction equation

HRID 1219369 reaction equation
[CH3:31][C:32](=[O:33])[OH:34].[Cl:1][c:2]1[c:3](-[c:10]2[nH:11][c:12](=[O:30])[c:13](-[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[cH:14][c:15]2[C:16](=[O:17])[N:18]2[CH2:19][CH:20]([O:22][CH3:23])[CH2:21]2)[c:4]([C:8]#[N:9])[cH:5][cH:6][cH:7]1.[OH2:36].[Zn:35]>>[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[CH2:8][n:11]1[c:10]-2[c:15]([C:16](=[O:17])[N:18]2[CH2:19][CH:20]([O:22][CH3:23])[CH2:21]2)[cH:14][c:13](-[c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:12]1=[O:30]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 23994ZincHCID 197854571-[[2-(2-Chloro-6-cyanophenyl)-1,6-dihydro-6-oxo-5-phenyl-3-pyridyl]carbonyl]-3-methoxyazetidine

Product 1

HCID 189570571-[(10-Chloro-4,6-dihydro-4-oxo-3-phenylpyrido[2,1-a]isoindole-1-yl)carbonyl]-3-methoxyazetidine

Sources & evidence

ORD record
ord-2c98eb39c2ec48498ed484810b6cd633
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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