Methyl 4-(1-bromoethyl)benzoate → 4-(1-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-ethyl)-benzoic acid methyl ester

HRID 1219489Notes

Reaction equation

HRID 1219489 reaction equation
[CH3:35][O:36][C:37]([c:38]1[cH:39][cH:40][c:41]([CH:44]([CH3:45])[Br:46])[cH:42][cH:43]1)=[O:47].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][O:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[F:22])[CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]2)[cH:29][c:30]([F:34])[c:31]([F:33])[cH:32]3)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][O:15][CH:44]([c:41]2[cH:40][cH:39][c:38]([C:37]([O:36][CH3:35])=[O:47])[cH:43][cH:42]2)[CH3:45])[CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]2)[cH:29][c:30]([F:34])[c:31]([F:33])[cH:32]3)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 12342351Methyl 4-(1-bromoethyl)benzoateHCID 461844412-(4-Chloro-phenyl)-1-[1-cyclohexyl-2-(2-fluoro-phenoxy)-ethyl]-5,6-difluoro-1H-benzoimidazole

Product 1

HCID 666195204-(1-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-ethyl)-benzoic acid methyl ester

Sources & evidence

ORD record
ord-fb1b91b700024a42abb4f1dd0a3cd683
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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