2-Aminocyclohexanol → 5-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

HRID 1219657Notes

Reaction equation

HRID 1219657 reaction equation
[Br:1][c:2]1[c:3]([O:15][CH2:16][C:17]([F:18])([F:19])[F:20])[n:4][c:5]([C:11]([F:12])([F:13])[F:14])[c:6]([C:7](=[O:8])[OH:9])[cH:10]1.[NH2:21][CH:22]1[CH:23]([OH:28])[CH2:24][CH2:25][CH2:26][CH2:27]1>>[Br:1][c:2]1[c:3]([O:15][CH2:16][C:17]([F:18])([F:19])[F:20])[n:4][c:5]([C:11]([F:12])([F:13])[F:14])[c:6]([C:7](=[O:9])[NH:21][CH:22]2[CH:23]([OH:28])[CH2:24][CH2:25][CH2:26][CH2:27]2)[cH:10]1

Participants

3

Reactant 2

HCID 232862-AminocyclohexanolHCID 863463205-Bromo-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)nicotinic acid

Product 1

HCID 866348035-Bromo-N-((1RS,2SR)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

Sources & evidence

ORD record
ord-110d2dc2165548d0beec188c2bcb0be0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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