Potassium Cation → 2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-6-(tert-butoxycarbonyl)-1-phenyl-8-(prop-2-enyl)-8-azabicyclo[3.2.1]octane

HRID 1220807Notes

Reaction equation

HRID 1220807 reaction equation
[C:38](=[O:39])([O-:40])[O-:41].[CH2:44]([CH:45]=[CH2:46])[Br:47].[CH3:48][CH2:49][O:50][CH2:51][CH3:52].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][O:14][CH:15]2[C:16]3([c:30]4[cH:31][cH:32][cH:33][cH:34][cH:35]4)[CH2:17][CH:18]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH:19]([CH2:20][CH2:21]2)[NH:22]3)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:36])[F:37].[K+:42].[K+:43]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][O:14][CH:15]2[C:16]3([c:30]4[cH:31][cH:32][cH:33][cH:34][cH:35]4)[CH2:17][CH:18]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH:19]([CH2:20][CH2:21]2)[N:22]3[CH2:46][CH:45]=[CH2:44])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:36])[F:37]

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 3283Diethyl EtherHCID 7841Allyl bromideHCID 19660Carbonate IonHCID 88039391Tert-butyl 2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1-phenyl-8-azabicyclo[3.2.1]octane-6-carboxylate

Product 1

HCID 865867082-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-6-(tert-butoxycarbonyl)-1-phenyl-8-(prop-2-enyl)-8-azabicyclo[3.2.1]octane

Sources & evidence

ORD record
ord-2fe8f5c423cb436b8717465ed8371d39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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