Pyridine → 2-Chloro-4-{[1-(3-fluoro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-benzoic acid methyl ester

HRID 1220882Notes

Reaction equation

HRID 1220882 reaction equation
[CH3:12][O:13][C:14]([c:15]1[c:16]([Cl:34])[cH:17][c:18]([NH:21][C:22](=[O:23])[c:24]2[cH:25][cH:26][c:27]3[c:32]([cH:33]2)[NH:31][CH2:30][CH2:29][CH2:28]3)[cH:19][cH:20]1)=[O:35].[Cl:42][CH2:43][Cl:44].[F:1][c:2]1[cH:3][c:4]([S:8](=[O:9])(=[O:10])[Cl:11])[cH:5][cH:6][cH:7]1.[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[F:1][c:2]1[cH:3][c:4]([S:8](=[O:9])(=[O:10])[N:31]2[CH2:30][CH2:29][CH2:28][c:27]3[cH:26][cH:25][c:24]([C:22]([NH:21][c:18]4[cH:17][c:16]([Cl:34])[c:15]([C:14]([O:13][CH3:12])=[O:35])[cH:20][cH:19]4)=[O:23])[cH:33][c:32]32)[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 686967962-Chloro-4-[(1,2,3,4-tetrahydro-quinoline-7-carbonyl)-amino]-benzoic acid methyl ester

Product 1

HCID 686978212-Chloro-4-{[1-(3-fluoro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-benzoic acid methyl ester

Sources & evidence

ORD record
ord-aabc3ef808894393abbac10af3f7fbee
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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