Pyridine → Buloxibutid

HRID 1221111Notes

Reaction equation

HRID 1221111 reaction equation
[Cl:37][C:38](=[O:39])[O:40][CH2:41][CH2:42][CH2:43][CH3:44].[N:26]1([c:27]2[cH:28][cH:29][cH:30][cH:31][n:32]2)[CH2:33][CH2:34][CH2:35][CH2:36]1.[cH:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1.[n:1]1([CH2:6][c:7]2[cH:8][cH:9][c:10](-[c:13]3[c:14]([S:22](=[O:23])(=[O:24])[NH2:25])[s:15][c:16]([CH2:18][CH:19]([CH3:20])[CH3:21])[cH:17]3)[cH:11][cH:12]2)[cH:2][n:3][cH:4][cH:5]1>>[n:1]1([CH2:6][c:7]2[cH:8][cH:9][c:10](-[c:13]3[c:14]([S:22](=[O:23])(=[O:24])[NH:25][C:38](=[O:39])[O:40][CH2:41][CH2:42][CH2:43][CH3:44])[s:15][c:16]([CH2:18][CH:19]([CH3:20])[CH3:21])[cH:17]3)[cH:11][cH:12]2)[cH:2][n:3][cH:4][cH:5]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 61140Butyl chloroformateHCID 110190202-(Pyrrolidin-1-yl)pyridineHCID 113947443(4-Imidazol-1-ylmethylphenyl)5-iso-butylthiophene-2 sulfonamide

Product 1

HCID 9804984Buloxibutid

Sources & evidence

ORD record
ord-8308f220031b443085a8a09586fb2c34
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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