(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone → 1'-({6-Chloro-1-[(3-fluorooxetan-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]

HRID 1222074Notes

Reaction equation

HRID 1222074 reaction equation
[Br:27][CH2:28][C:29]1([F:33])[CH2:30][O:31][CH2:32]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][CH2:18][c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:25][CH2:26]3)[cH:7][nH:8][c:9]2[cH:10]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][C:16]4([O:17][CH2:18][c:19]5[c:20]4[cH:21][cH:22][cH:23][cH:24]5)[CH2:25][CH2:26]3)[cH:7][n:8]([CH2:28][C:29]3([F:33])[CH2:30][O:31][CH2:32]3)[c:9]2[cH:10]1

Participants

3

Reactant 2

HCID 15951937(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanoneHCID 221608003-(Bromomethyl)-3-fluorooxetane

Product 1

HCID 596576921'-({6-Chloro-1-[(3-fluorooxetan-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]

Sources & evidence

ORD record
ord-6f4ff1fc98da4c4894a33da121f0513a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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