Ethylene Glycol → Brofaromine

HRID 1222096Notes

Reaction equation

HRID 1222096 reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:22][CH3:23])[cH:5][c:6]2[cH:7][c:8]([CH:11]3[CH2:12][CH2:13][N:14]([C:17]([O:18][CH2:19][CH3:20])=[O:21])[CH2:15][CH2:16]3)[o:9][c:10]12.[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[K+:25].[OH-:24].[OH:26][CH2:27][CH2:28][OH:29]>>[Br:1][c:2]1[cH:3][c:4]([O:22][CH3:23])[cH:5][c:6]2[cH:7][c:8]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[o:9][c:10]12

Participants

6

Reactant 5

HCID 174Ethylene GlycolHCID 813Potassium CationHCID 961HydroxideHCID 1140TolueneHCID 111434314-(7-Bromo-5-methoxy-benzofuran-2-yl)-1-ethoxycarbonyl-piperidine

Product 1

HCID 44571Brofaromine

Sources & evidence

ORD record
ord-aa221333fc954138be78d0fea28bd3be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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