2-chloro-N,N-dimethylacetamide → 2-{6-[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-3,4-dihydro-1H-isoquinolin-2-yl}-N,N-dimethyl-acetamide

HRID 122216Notes

Reaction equation

HRID 122216 reaction equation
[CH3:1][O:2][c:3]1[c:4](-[c:13]2[c:14]3[n:15]([cH:16][cH:17][cH:18]2)[n:19][c:20]([NH:22][c:23]2[cH:24][c:25]4[c:30]([cH:31][cH:32]2)[CH2:29][NH:28][CH2:27][CH2:26]4)[n:21]3)[cH:5][c:6]([C:9]([F:10])([F:11])[F:12])[cH:7][cH:8]1.[Cl:33][CH2:34][C:35](=[O:36])[N:37]([CH3:38])[CH3:39]>>[CH3:1][O:2][c:3]1[c:4](-[c:13]2[c:14]3[n:15]([cH:16][cH:17][cH:18]2)[n:19][c:20]([NH:22][c:23]2[cH:24][c:25]4[c:30]([cH:31][cH:32]2)[CH2:29][N:28]([CH2:34][C:35](=[O:36])[N:37]([CH3:38])[CH3:39])[CH2:27][CH2:26]4)[n:21]3)[cH:5][c:6]([C:9]([F:10])([F:11])[F:12])[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 49838140[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl]-(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amine

Product 1

HCID 596125062-{6-[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-3,4-dihydro-1H-isoquinolin-2-yl}-N,N-dimethyl-acetamide

Sources & evidence

ORD record
ord-00b16d468529464588daa29ec27fbbed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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