6-[3-[4-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]piperidine-1-carbonyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide → 6-[3-[4-[[2-[3-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]piperidine-1-carbonyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
Reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:5][CH:6]([c:7]1[cH:8][cH:9][c:50]([OH:51])[c:52]2[c:53]1[cH:54][cH:55][c:56](=[O:57])[nH:58]2)[CH2:59][NH:60][CH:10]1[CH2:11][CH2:12][N:13]([C:16](=[O:17])[c:18]2[cH:19][c:20]([S:24](=[O:25])(=[O:26])[c:27]3[cH:28][c:29]4[c:30]([NH:41][c:42]5[cH:43][c:44]([O:48][CH3:49])[cH:45][cH:46][cH:47]5)[c:31]([C:38](=[O:39])[NH2:40])[cH:32][n:33][c:34]4[c:35]([CH3:37])[cH:36]3)[cH:21][cH:22][cH:23]2)[CH2:14][CH2:15]1)([CH3:61])([CH3:62])[CH3:63].[NH2:64][CH2:65][CH:66]([OH:67])[c:68]1[cH:69][c:70]([CH2:75][O:76][Si:77]([CH3:78])([CH3:79])[C:80]([CH3:81])([CH3:82])[CH3:83])[c:71]([OH:74])[cH:72][cH:73]1>>[CH:10]1([NH:64][CH2:65][CH:66]([OH:67])[c:68]2[cH:69][c:70]([CH2:75][O:76][Si:77]([CH3:78])([CH3:79])[C:80]([CH3:81])([CH3:82])[CH3:83])[c:71]([OH:74])[cH:72][cH:73]2)[CH2:11][CH2:12][N:13]([C:16](=[O:17])[c:18]2[cH:19][c:20]([S:24](=[O:25])(=[O:26])[c:27]3[cH:28][c:29]4[c:30]([NH:41][c:42]5[cH:43][c:44]([O:48][CH3:49])[cH:45][cH:46][cH:47]5)[c:31]([C:38](=[O:39])[NH2:40])[cH:32][n:33][c:34]4[c:35]([CH3:37])[cH:36]3)[cH:21][cH:22][cH:23]2)[CH2:14][CH2:15]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-45ceaa538777499fb3962b5be9b1e10e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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