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2-Methylnicotinic acid → (S)-6,6-Dimethyl-4-((S)-2-[(2-methyl-pyridine-3-carbonyl)amino]propyl)-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylnicotinic acid | HCID 643373 | — |
| 反応物 | (s)-4-((s)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9h-beta-carbolin-8-yl)-amide trifluoroacetate salt | HCID 67165199 | — |
| 生成物 | (S)-6,6-Dimethyl-4-((S)-2-[(2-methyl-pyridine-3-carbonyl)amino]propyl)-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide | HCID 59337522 | 75% |
反応手順
The desired compound was prepared according to Method E from (S)-4-((S)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide trifluoroacetate salt and 2-methyl-nicotinic acid in 75% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727985B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f0e5fa4ede3b47dca9055aebff913347 |
| 出典メモ | uspto-grants-2010_06 |