Acetic Acid → Apremilast, (+-)-

HRID 1223353Notes

Reaction equation

HRID 1223353 reaction equation
[C:19]([CH3:20])(=[O:21])[NH:22][c:23]1[c:24]2[c:25]([cH:31][cH:32][cH:33]1)[C:26](=[O:27])[O:28][C:29]2=[O:30].[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][c:6]([CH:12]([CH2:13][S:14](=[O:15])(=[O:16])[CH3:17])[NH2:18])[cH:7][cH:8][c:9]1[O:10][CH3:11].[CH3:34][C:35](=[O:36])[OH:37]>>[CH2:1]([CH3:2])[O:3][c:4]1[cH:5][c:6]([CH:12]([CH2:13][S:14](=[O:15])(=[O:16])[CH3:17])[N:18]2[C:26](=[O:27])[c:25]3[c:24]([c:23]([NH:22][C:19]([CH3:20])=[O:21])[cH:33][cH:32][cH:31]3)[C:29]2=[O:28])[cH:7][cH:8][c:9]1[O:10][CH3:11]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 2261213-Acetamidophthalic AnhydrideHCID 112887921-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine

Product 1

HCID 10151715Apremilast, (+-)-

Sources & evidence

ORD record
ord-be701e6877dc4f5e9826689991ed0e22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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