Imidazole → Tert-butyl{[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methoxy}dimethylsilane

HRID 1223405Notes

Reaction equation

HRID 1223405 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[Cl:8].[Cl:39][CH2:40][Cl:41].[F:14][c:15]1[cH:16][c:17]([O:36][CH3:37])[c:18](-[c:24]2[c:25]([CH2:34][OH:35])[cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]2)[cH:19][c:20]1[CH:21]([CH3:22])[CH3:23].[OH2:38].[nH:9]1[cH:10][cH:11][n:12][cH:13]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:35][CH2:34][c:25]1[c:24](-[c:18]2[c:17]([O:36][CH3:37])[cH:16][c:15]([F:14])[c:20]([CH:21]([CH3:22])[CH3:23])[cH:19]2)[cH:29][cH:28][c:27]([C:30]([F:31])([F:32])[F:33])[cH:26]1

Participants

6

Reactant 5

HCID 795ImidazoleHCID 962WaterHCID 6344DichloromethaneHCID 28928tert-Butyldimethylsilyl chlorideHCID 533638284'-Fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)(1,1'-biphenyl)-2-methanol

Product 1

HCID 66717161Tert-butyl{[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methoxy}dimethylsilane

Sources & evidence

ORD record
ord-7443d19d38594ee09e7db2d5eed69a06
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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