2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-2-({[1-(4-fluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

HRID 1223612Notes

Reaction equation

HRID 1223612 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]2([C:13]([F:14])([F:15])[F:16])[O:11][CH2:12]2)([CH3:17])[CH3:18])[cH:7]1.[F:21][c:22]1[cH:23][cH:24][c:25](-[n:28]2[n:29][cH:30][c:31]3[c:32]([NH2:37])[cH:33][cH:34][cH:35][c:36]23)[cH:26][cH:27]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]([OH:11])([CH2:12][NH:37][c:32]2[c:31]3[cH:30][n:29][n:28](-[c:25]4[cH:24][cH:23][c:22]([F:21])[cH:27][cH:26]4)[c:36]3[cH:35][cH:34][cH:33]2)[C:13]([F:14])([F:15])[F:16])([CH3:17])[CH3:18])[cH:7]1

Participants

3

Reactant 2

HCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 249380581-(4-Fluorophenyl)-1H-indazol-4-amine

Product 1

HCID 576159311,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-2-({[1-(4-fluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

Sources & evidence

ORD record
ord-4136c5fd311e48408c6d09e82b4b152a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…