1-[(3,5-Difluorophenyl)methyl]piperidin-4-amine → 5-(5-{[1-(3,5-Difluoro-benzyl)-piperidin-4-ylamino]-methyl}-thiophen-2-yl)-3-ethyl-6-methyl-1H-pyridin-2-one
Reaction equation
[CH2:1]([CH3:2])[c:3]1[cH:4][c:5](-[c:11]2[cH:12][cH:13][c:14]([CH:16]=[O:17])[s:15]2)[c:6]([CH3:10])[nH:7][c:8]1=[O:9].[F:18][c:19]1[cH:20][c:21]([CH2:22][N:23]2[CH2:24][CH2:25][CH:26]([NH2:29])[CH2:27][CH2:28]2)[cH:30][c:31]([F:33])[cH:32]1>>[CH2:1]([CH3:2])[c:3]1[cH:4][c:5](-[c:11]2[cH:12][cH:13][c:14]([CH2:16][NH:29][CH:26]3[CH2:25][CH2:24][N:23]([CH2:22][c:21]4[cH:20][c:19]([F:18])[cH:32][c:31]([F:33])[cH:30]4)[CH2:28][CH2:27]3)[s:15]2)[c:6]([CH3:10])[nH:7][c:8]1=[O:9]Participants
3
Sources & evidence
- ORD record
- ord-fcd655d9c8144b71bdb14f551e6c98f7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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