Tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylate → tert-Butyl 3-[4-ethoxy-3-(3-methoxypropoxy)benzyloxy]-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

HRID 1224337Notes

Reaction equation

HRID 1224337 reaction equation
[Br:35][CH2:36][c:37]1[cH:38][c:39]([O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[c:40]([O:43][CH2:44][CH3:45])[cH:41][cH:42]1.[OH:1][CH:2]1[CH2:3][N:4]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][c:20]2[c:21]([O:26][CH3:27])[cH:22][cH:23][cH:24][cH:25]2)[cH:12][cH:13]1>>[O:1]([CH:2]1[CH2:3][N:4]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][c:20]2[c:21]([O:26][CH3:27])[cH:22][cH:23][cH:24][cH:25]2)[cH:12][cH:13]1)[CH2:36][c:37]1[cH:38][c:39]([O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[c:40]([O:43][CH2:44][CH3:45])[cH:41][cH:42]1

Participants

3

Reactant 2

HCID 15546933Tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylateHCID 685032054-Bromomethyl-1-ethoxy-2-(3-methoxypropoxy)benzene

Product 1

HCID 68504392tert-Butyl 3-[4-ethoxy-3-(3-methoxypropoxy)benzyloxy]-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Sources & evidence

ORD record
ord-6be32388cad64bc0b03edb2bb717a890
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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